Side effects of chlorthalidone (by mouth) (2023)

Description and brand name

Drug information provided by:IBM Micromedex

american brand

  1. Talton


Chlorthalidone is used alone or in combination with other medications to treat high blood pressure (hypertension). High blood pressure increases the workload on the heart and arteries. If it continues for a long time, the heart and arteries may not work properly. This can damage the blood vessels in the brain, heart, and kidneys, which can lead to stroke, heart failure, or kidney failure. High blood pressure can also increase the risk of heart attacks. These problems are less likely to occur when your blood pressure is controlled.

Chlorthalidone is also used to treat fluid buildup (edema) caused by congestive heart failure, severe liver disease (cirrhosis), kidney disease, or treatment with a hormone or steroid medication.

Chlorthalidone is a diuretic (water pill). Reduces the amount of water in the body by increasing the flow of urine, which helps lower blood pressure.

This medication can only be obtained with a prescription.

This product is available in the following dosage forms:

  • planks

Before using

When deciding on a medication, the risks of taking it must be weighed against the benefits. This is a decision for you and your doctor to make. Things to keep in mind about this drug:


Tell your doctor if you have ever had an unusual or allergic reaction to this medicine or any other medicine. Also, tell your doctor if you have any other allergies, such as B. against foods, dyes, preservatives, or animals. For over-the-counter products, read the ingredient label or packaging carefully.


Appropriate studies of the association of age with the effects of chlorthalidone in children and adolescents have not been performed. Safety and efficacy have not been established.

(Video) Chlorthalidone (Thalitone) - Uses, Dosing, Side Effects


Appropriate studies conducted to date have not revealed any specific geriatric problems that limit the usefulness of chlorthalidone in the elderly. However, elderly patients are more prone to age-related renal disease, which may require caution and dose adjustment in patients receiving chlorthalidone.


There are not enough studies in women to determine the risk to babies from using this medicine while breastfeeding. Weigh the potential benefits against the potential risks before using this medicine while breastfeeding.

Interactions with other drugs

While certain drugs should not be used together, in other cases two different drugs can be used together even if an interaction occurs. In these cases, your doctor may change the dose or other precautions may be necessary. If you are taking this medicine, it is especially important that your doctor knows if you are taking any of the medicines listed below. The following interactions have been selected for their potential importance and are not necessarily exhaustive.

The use of this medicine with any of the following medicines is generally not recommended, but may be necessary in some cases. If both drugs are prescribed together, your doctor may change the dose or frequency of use of one or both drugs.

  • aceclofenaco
  • Acemethacin
  • acetyldigoxin
  • salbutamol
  • Amtolmetina Guacil
  • arsenic trioxide
  • Aspirin
  • baby shower
  • bromfenaco
  • bufexamac
  • celecoxibe
  • colinsalicilato
  • clonixina
  • Deslanoside
  • desmopresina
  • dexibuprofen
  • dexketoprofeno
  • diclofenac
  • diflunisal
  • Digital
  • Digitoxina
  • digoxin
  • Pinned
  • dofetilida
  • droperidol
  • Droxicam
  • Etodolacus
  • Etofenamato
  • etoricoxib
  • Felbinac
  • fenoprofen
  • fepradinol
  • feprazon
  • Flecainide
  • floctafenine
  • flufenamic acid
  • flurbiprofen
  • Ibuprofen
  • indomethacin
  • Chain
  • ketoprofen
  • cetorolaco
  • About levometa
  • Lithium
  • Lornoxicam
  • loxoprofen
  • luracoxib
  • meclofenamato
  • mefenamic acid
  • Meloxicam
  • Methyldigoxin
  • morniflumato
  • Nabumetona
  • naproxen
  • Nepafenaco
  • nifluminic acid
  • name brackets
  • Nimesulide Beta Cyclodextrin
  • Oxaprocin
  • oxifenbutazona
  • parecoxib
  • Phenylbutazone
  • picetoprofen
  • Piroxicam
  • proglumethacin
  • prophenazone
  • proquazon
  • rofecoxib
  • salicylic acid
  • salad salad
  • sodium salicylate
  • Sotalol
  • Sulindac
  • tenoxicam
  • tiaprofenic acid
  • tolfenamic acid
  • tolmet
  • Valdecoxib

Using this medication with any of the following medications may increase the risk of certain side effects, but using both medications may be the best treatment for you. If both drugs are prescribed together, your doctor may change the dose or frequency of use of one or both drugs.

  • aminolevulinic acid
  • gossip
  • licorice
  • warfarin

Other interactions

Certain medications should not be used at the time of eating or eating certain types of food because interactions can occur. The use of alcohol or tobacco with certain medications can also lead to interactions. Talk to your doctor about taking your medication with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may interfere with the use of this medicine. Be sure to tell your doctor if you have any other medical problems, especially:

  • Anuria (inability to produce urine): It should not be used in patients with this condition.
  • asthma o
  • dehydration or
  • diabetes o
  • release the
  • Hypercalcemia (high levels of calcium in the blood) or
  • Hyperlipidemia (elevated cholesterol or triglycerides in the blood) or
  • Hyperuricemia (high uric acid in the blood) or
  • Hypochloremic alkalosis (low levels of chlorine in the blood) or
  • hypokalemia (low levels of potassium in the blood) or
  • hypomagnesemia (low levels of magnesium in the blood) or
  • hyponatremia (low levels of sodium in the blood) or
  • hypophosphatemia (low levels of phosphate in the blood) or
  • hypotension (low blood pressure)
  • Hypovolemia (low blood volume) or
  • kidney failure or
  • Systemic lupus erythematosus - Use with caution. It can make these conditions worse.
  • kidney disease or
  • Liver disease - Use with caution. The effect of the drug may be enhanced due to the slower elimination of the drug from the body.

correct use

Take this medication exactly as prescribed by your doctor in order to improve your condition as much as possible. Do not take more, more often, or longer than your doctor has prescribed.

To help you remember to take your medicine, try to get into the habit of taking it at the same time every day.

(Video) Chlorthalidone side effects | common side effects of chlorthalidone tablets

In addition to using this medication, treatment of high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium or potassium. Your doctor will tell you which ones are most important to you. You should consult your doctor before changing your diet.

Many patients with high blood pressure do not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and keep your doctor's appointments, even if you feel fine.

Please note that this medication will not cure your high blood pressure, but it will help control it. You should continue to take it as directed if you hope to lower and maintain your blood pressure. You may need to take high blood pressure medication for the rest of your life. If left untreated, high blood pressure can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

This medicine is usually taken in the morning with a meal.


The dose of this medicine is different for different patients. Follow the directions of your doctor or the label. The information below contains only the average doses of this medication. If your dose is different, do not change it unless your doctor tells you to.

The amount of medicine you take depends on the strength of the medicine. Also, the number of doses you take each day, the time between doses, and how long you take the medication will depend on the condition for which you are using it.

  • For the oral dosage form (tablets):
    • For fluid retention (edema):
      • Adults: Initially 50 to 100 milligrams (mg) once a day or 100 mg once every other day. Your doctor may adjust your dose if necessary.
      • Children - Use and dosage should be determined by your doctor.
    • For high blood pressure:
      • Adult-
        • Chlorthalidone: Initially 25 milligrams (mg) once a day. Your doctor may adjust your dose if necessary.
        • Thalitone®: Initially 15 mg once a day. After 2 weeks, your dose may be increased to 25 mg daily as needed.
      • Children - Use and dosage should be determined by your doctor.

missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

save to computer

Store the medication in a closed container at room temperature away from heat, moisture, and direct light. avoid freezing.

Stay away from children.

(Video) What are the common side effects of Chlorthalidone?

Do not keep medications that have expired or are no longer needed.

Ask your doctor how to dispose of any unused medicine.


It is very important that your doctor check your progress at regular visits to make sure this medication is working properly. Blood tests may be needed to check for unwanted effects.

It may cause dizziness, dizziness, or fainting, especially if you get up suddenly from a lying or sitting position. Standing up slowly can help. If the problem persists or worsens, see your doctor.

This medication may cause you to lose more potassium from your body than normal (hypokalemia). Tell your doctor if you develop severe or persistent nausea, vomiting, or diarrhea, and drink fluids to prevent dehydration. See your doctor immediately if you experience dry mouth, increased thirst, muscle cramps, nausea, or vomiting.

This medicine may cause dizziness in some people. Do not drive, use machines or do anything that could be dangerous if you get dizzy.

Drinking alcohol can also make dizziness worse. While taking this medication, be sure to limit the amount of alcohol you drink.

Do not take any other medication unless you have discussed it with your doctor. Specifically, this includes prescription and over-the-counter (OTC) medications for appetite control, asthma, colds, coughs, hay fever, or sinus problems.

side effects

In addition to the necessary effects, a drug may have some undesirable effects. Although not all of these side effects can occur, they may require medical attention if they do occur.

(Video) What are the side effects of chlorthalidone?

Contact your doctor immediately if you experience any of the following side effects:

unknown incidence

  1. abdominal or stomach pain
  2. black, tarry stools
  3. bleeding gums
  4. blistering, peeling, or loosening of the skin
  5. swelling
  6. blood in the urine or stool
  7. blurry vision
  8. Burning sensation, tingling, itching, numbness, tingling, tingling, or itching
  9. chest pain
  10. shaking chills
  11. clay colored chairs
  12. cold sweat
  13. confusion
  14. cough or hoarseness
  15. cough up blood
  16. dark urine
  17. Diarrhea
  18. Difficulty passing stool (stool)
  19. Dizziness, fainting, or lightheadedness when you get up suddenly from lying down or sitting up
  20. dry mouth
  21. racing heartbeat
  22. Fever
  23. dry and red skin
  24. fruity breath
  25. general feeling of tiredness or weakness
  26. Headache
  27. increased hunger
  28. elevation from seat
  29. increased urination
  30. indigestion
  31. picazón or sarpullido
  32. Pain, stiffness or swelling in the joints
  33. Appetitverlust
  34. lumbar or lateral pain
  35. nausea
  36. joint or muscle pain
  37. painful or difficult urination
  38. Abdominal, side, or abdominal pain that may radiate to the back
  39. detect red spots on the skin
  40. red and irritated eyes
  41. red skin lesions, often with a purple center
  42. Redness, pain, or itching on the skin
  43. sore throat
  44. Sores, ulcers, or white patches on the lips or inside the mouth
  45. sores, welts, or blisters
  46. sugar in urine
  47. Sweat
  48. swelling of the feet or legs
  49. Inflamed glands
  50. chest tightness
  51. labored breathing
  52. bad breath
  53. unusual bleeding or bruising
  54. unusual tiredness or weakness
  55. unusual weight loss
  56. to vomit
  57. vomit blood
  58. weightloss
  59. yellow eyes or skin

There may be some side effects that usually do not require medical attention. These side effects may go away during treatment as your body gets used to the medicine. Also, your doctor can tell you about ways to prevent or reduce some of these side effects. Contact your doctor if any of the following side effects persist or bother you, or if you have any questions:

unknown incidence

  1. electric shock
  2. decreased interest in sex
  3. Sensation of constant movement of oneself or the environment.
  4. Urticaria
  5. Inability to achieve or maintain an erection
  6. increased skin sensitivity to sunlight
  7. Loss of sexual ability, desire, motivation, or achievement
  8. Muscular cramp
  9. Redness or other discoloration of the skin
  10. concern
  11. spinning sensation
  12. severe sunburn
  13. weakness

Some patients may also experience other side effects not listed. If you notice other effects, consult your doctor.

Call your doctor for medical advice on side effects. You can report side effects to the FDA by calling 1-800-FDA-1088.

Parts of this document were last updated: March 1, 2023

Original article:

Copyright © 2023 IBM Watson Health. All rights reserved. The information is for the exclusive use of the end user and may not be sold, redistributed or used for commercial purposes.



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