Captopril Precautions (Oral Administration) - Mayo Clinic (2023)

Brand description and names

Drug information provided by:IBM Micromedex

american brand

  1. captain


Captopril is used alone or with other medicines to treat high blood pressure (hypertension). High blood pressure increases the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not be working properly. This can damage blood vessels in the brain, heart, and kidneys, leading to a stroke, heart failure, or kidney failure. Lowering blood pressure can reduce the risk of stroke and heart attack.

Captopril works by blocking a substance in the body that causes blood vessels to narrow. This relaxes the blood vessels. This lowers blood pressure and increases the flow of blood and oxygen to the heart.

Captopril is also used to treat heart failure. It is also used in some patients after a heart attack. After a heart attack, part of the heart muscle is damaged and weakened. The heart muscle can continue to weaken over time. This makes it harder for the heart to pump blood. Captopril can be started within the first few days after a heart attack to increase survival.

Captopril is also used to treat kidney problems caused by diabetes (diabetic nephropathy).

This medicine can only be obtained with a prescription.

This product is available in the following dosage forms:

  • Board

Before using

When deciding to take a medication, the risks of taking it must be weighed against the benefits. This is a decision that you and your doctor must make. For this drug, the following should be considered:


Tell your doctor if you have ever had an allergic or unusual reaction to this medicine or any other medicine. Also, tell your doctor if you have other allergies, such as B. against food, dyes, preservatives or animals. For over-the-counter products, read the ingredient label or package carefully.


No adequate studies have been conducted on the relationship between age and the effects of captopril in children and adolescents. Safety and effectiveness have not been established.

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There is no information on the relationship between age and the effects of captopril in geriatric patients. However, elderly patients are more prone to age-related kidney problems, which may require dose adjustments in patients receiving captopril.


There are no adequate studies in women to determine the risk to babies of using this medication while breastfeeding. Weigh the potential benefits against the potential risks before using this medication while breastfeeding.

Interactions with other drugs

While certain drugs should not be used together, in other cases, two different drugs can be used together even if an interaction occurs. In these cases your doctor may change the dose or other precautions may be necessary. If you are taking this medicine, it is especially important that your doctor knows if you are taking any of the medicines listed below. The following interactions have been selected for their potential importance and are not necessarily exhaustive.

The use of this medication with any of the following medications is not recommended. Your doctor may decide not to treat you with this medicine or change some of the other medicines you are taking.

  • Aliskirén
  • sacubitril

The use of this medication with any of the following medications is generally not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both medicines.

  • Alopurinol
  • Alteplasa, recombinant
  • Amor
  • Azatioprina
  • azilsartana
  • azilsartan medoxomil
  • candesartana
  • canrenoato
  • digoxin
  • doxorubicin
  • Doxorubicin-Hydrochloride-Liposome
  • eplerenona
  • Eprosartan
  • Everolimo
  • Furosemide
  • Interferon alfa-2a
  • irbesartana
  • Lithium
  • Losartan
  • Merkaptopurina
  • morphine
  • Morphinesulphato-Liposome
  • Nilotinib
  • olmesartan
  • Oxipurinol
  • Pixantron
  • Potassium
  • Kaliumcitrate
  • Sirolimo
  • Spironolactone
  • tacrolimus
  • Telmisartana
  • Triamtereno
  • Trimethoprim
  • valsartan toe

Using this medication with any of the following medications may increase your risk of certain side effects, but using both medications may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both medicines.

  • aceclofenaco
  • Acemethacin
  • Amtolmetina Guacil
  • Aspirin
  • Bromfenaco
  • bufexamac
  • Bumetanide
  • bupivacaina
  • Bupivacaine-Lipos
  • capsaicin
  • Celecoxibe
  • Chlorpromazine
  • Colinsalicilato
  • as Klonix
  • dexibuprofen
  • Dexcetoprofen
  • Diclofenac
  • diflunisal
  • dipyrone
  • Droxicam
  • ethacrynic acid
  • Etodolacus
  • Etofenamato
  • Etoricoxibe
  • Etozolina
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazon
  • Floctafenine
  • flufenamic acid
  • Flurbiprofen
  • sodium thiomalate gold
  • Ibuprofen
  • Ikatibant
  • indomethacin
  • Cetoprofen
  • cetorolaco
  • Lornoxicam
  • loxoprofen
  • luracoxibe
  • Meclofenamato
  • mefenamic acid
  • Meloxicam
  • morniflumato
  • nabumetonium
  • naproxen
  • nepafenaco
  • nesiritida
  • niflumic acid
  • name brackets
  • Nimesulide Beta Cyclodextrin
  • Oxaprocina
  • Oxifenbutazona
  • parecoxib
  • phenylbutazone
  • picetoprofen
  • Britannia
  • Piroxicam
  • pranoprofeno
  • Proglumethacin
  • propionic acid
  • prophenazone
  • Proquazon
  • Rofecoxibe
  • salicylic acid
  • Salad Salad
  • sodium salicylate
  • Sulindac
  • tenoxicam
  • tiaprofenic acid
  • tolfenamic acid
  • tolmet
  • Torsemida
  • Valdecoxib

Other interactions

Certain medications should not be used at or around the time of eating or consuming certain types of food because interactions may occur. Consumption of alcohol or tobacco with certain medications can also lead to interactions. The following interactions have been selected for their potential importance and are not necessarily exhaustive.

Other medical problems

The presence of other medical problems may affect the use of this medication. Be sure to let your doctor know if you have any other medical issues, especially:

  • Angioedema (swelling of the face, lips, tongue, throat, arms or legs), medical history: may increase the risk of recurrence of this condition.
  • Collagen vascular disease (an autoimmune disease) associated with kidney disease: increased risk of blood problems.
  • Electrolyte imbalance (such as low blood sodium levels) or
  • Fluid imbalances (caused by dehydration, vomiting, or diarrhea) or
  • Heart or blood vessel problems (for example, aortic stenosis) or
  • Liver disease - Use with caution. It can make these conditions worse.
  • Kidney problems (including dialysis patients): use with caution. The effect can be enhanced due to slower elimination of the drug from the body.

Fair Use

In addition to using this medication, treating high blood pressure may include controlling your weight and changing the types of foods you eat, particularly foods high in sodium (salt). Your doctor will tell you which ones are most important to you. You should consult your doctor before changing your diet.

Many patients with high blood pressure do not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and attend your doctor's appointments, even if you feel well.

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Remember that this medicine will not cure your high blood pressure, but it will help to control it. Therefore, you must continue to take it as directed if you wish to lower and keep your blood pressure low. You may need to take high blood pressure medication for the rest of your life. If left untreated, high blood pressure can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Take this medicine on an empty stomach at least 1 hour before meals.


The dose of this medicine is different for different patients. Follow your doctor's or label instructions. The information below only contains the average doses of this medication. If your dose is different, do not change it unless your doctor tells you to.

The amount of medicine you take depends on the strength of the medicine. Also, the number of doses you take each day, the time between doses, and how long you take the medication will depend on the medical condition you are using the medication for.

  • For the oral pharmaceutical form (tablets):
    • For high blood pressure:
      • Adults: 25 milligrams (mg) two to three times daily initially. Your doctor may increase your dose as needed. However, the dose is usually not more than 450 mg per day.
      • Children: The physician must determine the use and dosage.
    • For heart failure:
      • Adults: 25 milligrams (mg) three times daily initially. Your doctor may increase your dose as needed. However, the dose is usually not more than 450 mg per day.
      • Children: The physician must determine the use and dosage.
    • For treatment after a heart attack:
      • Adults: 6.25 milligrams (mg) initially as a single dose, then 12.5 mg three times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 450 mg per day.
      • Children: The physician must determine the use and dosage.
    • For kidney problems caused by diabetes:
      • Adults: 25 milligrams (mg) three times daily.
      • Children: The physician must determine the use and dosage.

missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the doses.


Store the medicine in a closed container at room temperature, away from heat, moisture and direct light. Prevent it from freezing.

Keep away from children.

Do not store expired or no longer needed medications.

Ask your doctor how to throw away unused medicines.


It is very important for your doctor to check your progress at regular visits to make sure this medication is working properly. Blood and urine tests may be needed to check for adverse effects.

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Using this medication during pregnancy may harm an unborn baby. Use an effective form of birth control to prevent pregnancy. If you think you may have become pregnant while using this medication, tell your doctor right away.

You must not use this medication together with Sacubitril. Do not use this medication and Sacubitril/Valsartan (Entresto®) within 36 hours.

This medication can cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you develop a rash, itching, hoarseness, difficulty breathing, swallowing, or swelling of your hands, face, mouth, or throat while using this medication.

Call your doctor right away if you experience severe stomach pain (with or without nausea or vomiting). This could be a symptom of a condition called intestinal angioedema.

Dizziness, lightheadedness, or fainting may also occur, especially if you get up suddenly from a lying or sitting position, or if you have taken a diuretic (water pill). Do not drive or do anything that could be dangerous until you or your child know how this medicine affects you. If you get dizzy, lie down to avoid passing out. Then sit for a few moments before getting up to prevent the dizziness from returning.

Contact your doctor right away if you get sick while taking this medication, especially if you have severe or persistent nausea, vomiting, or diarrhea. These conditions can cause you to lose too much water or salt and cause low blood pressure. You can also lose water through sweating, so drink plenty of water when exercising or in hot weather.

Contact your doctor if you have a fever, chills or sore throat. These could be symptoms of an infection caused by a low white blood cell count.

Contact your doctor immediately if you experience upper abdominal pain or tenderness, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellowing eyes or skin. These could be symptoms of a serious liver problem.

Contact your doctor immediately if you have blood in your urine, decreased frequency or amount of urination, increased blood pressure, increased thirst, loss of appetite, pain in your lower back or sides, nausea, swelling of your face, fingers or lower legs, difficulty breathing, unusual tiredness or weakness, vomiting or weight gain. These could be symptoms of a serious kidney problem.

Hyperkalemia (high levels of potassium in the blood) may occur while using this medication. Contact your doctor right away if you have the following symptoms: abdominal or stomach pain, confusion, difficulty breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in your hands, feet, or lips, difficulty breathing, or weakness or heaviness on your legs. Do not use potassium-containing supplements or salt substitutes without first consulting your physician.

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Make sure any doctor or dentist who is treating you knows that you are using this medicine. You may need to stop using this medication several days before an operation or medical tests.

This medication may be less effective in black patients. Black patients are also at greater risk for angioedema (swelling of the hands, arms, face, mouth, or throat).

Do not take any other medication unless you have discussed this with your doctor. These include prescription or over-the-counter (OTC) medications for appetite control, asthma, colds, coughs, hay fever, or sinus problems, as well as herbal or vitamin supplements, as they can raise your blood pressure.

Side effects

In addition to the necessary effects, a drug can have some undesirable effects. While not all of these side effects may occur, they may require medical attention if they do.

Contact your doctor immediately if you experience any of the following side effects:

less common

  1. chest pain
  2. urina safety
  3. fast, pounding, or irregular pulse or heartbeat


  1. Arm, back or jaw pain
  2. urine with blood
  3. chest discomfort
  4. Tightness or heaviness in the chest
  5. Decreased blood pressure
  6. Decreased or increased frequency or amount of urination
  7. dilated jugular veins
  8. Raise from seat
  9. irregular breathing
  10. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  11. Appetitverlust
  12. low blood pressure
  13. Back or side pain
  14. nausea
  15. pale or cold feeling in the tips of the fingers and toes
  16. sweat
  17. Swelling of the face, fingers, feet or legs
  18. Tingling or pain in the fingers or toes when exposed to cold temperatures
  19. difficulty breathing
  20. unusual tiredness or weakness
  21. To vomit
  22. weight gain

unknown incidence

  1. bleeding gums
  2. bloody, black, or tarry stools
  3. blurry vision
  4. chills
  5. confusion
  6. for
  7. Dizziness, fainting, or lightheadedness when you get up suddenly from a lying or sitting position
  8. high fever
  9. painful or difficult urination
  10. pale skin
  11. indicate red spots on the skin
  12. sore throat
  13. Sores, ulcers, or white patches on the lips or inside the mouth
  14. inflamed glands
  15. unusual bleeding or bruising

There may be some side effects that usually do not require medical attention. These side effects may go away during treatment as your body gets used to the medicine. Also, your doctor can tell you about ways to prevent or reduce some of these side effects. Contact your doctor if any of the following side effects persist or bother you, or if you have any questions about them:

less common

  1. change of taste
  2. hot feeling
  3. itchy skin
  4. loss of taste
  5. skin irritation
  6. Redness of the face, neck, arms and occasionally upper chest

Some patients may also experience other side effects not listed. If you notice other effects, contact your doctor.

Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Parts of this document last updated: February 1, 2023

Original article:

(Video) Lisinopril Side Effects

Copyright © 2023 IBM Watson Health. All rights reserved. The information is intended solely for the end user and may not be sold, redistributed or used for commercial purposes.



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